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DNA Mutations and Methylation Part 6


Let’s look at the Gene Mutation AHCY.  AHCY plays a part in the methylation pathway in breaking down methionine.  An AHCY mutation might lead to a deficiency of SAM-e.   

Possible symptoms of AHCY mutation: 

  • Depression

  • Arthritis

  • Fibromyalgia

  • Ischemic Stroke

What causes depression?    Depression may be linked to a lack of serotonin. Some drugs formulated to help with depression are called SSRIs (Selective Serotonin Reuptake Inhibitors).   Because your body may not be making enough serotonin, then SSRIs, in theory, help you recycle it better.  But why not address why serotonin is low in the first place?   90% of serotonin is made in the gut.   And the gut is affected by a lack of methylated B vitamins.  See the connection?  By fixing the gut and restoring the proper pathways, serotonin production can get back to normal and relieve symptoms of depression. 

What supplements might help?   

1.       Methylfolate and other methylated B vitamins.   You need these to make proper amounts of stomach acid.

2.       SAM-e:  Please listen to this podcast before trying, SAMe doesn’t work for everyone.

Want to learn more?  

Listen to Gary Brecka connect Depression with poor methylation:

Statistics about Mental Health Conditions:


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