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Peptide Spotlight: TB500

Heal Injuries Like Wolverine!

Primary Benefit: Promotes joint, tissue, muscle and ligament regeneration and wound repair.  Promotes migration of cells, formation of blood vessels, maturation of stem cells, survival of various cell types and reduction of pro-inflammatory cytokines. TB500 is an excellent immune modulator.


  • Improved musculoskeletal, joint, and wound repair

  • Increased endurance and strength

  • Improved chronic fatigue

  • Improved muscle tone

  • Suppressed muscle spasms

  • Improved auto-immune function

  • Protection against oxidative damage

  • Can protect heart tissue during events such as heart attacks and myocardial infarctions (a COMMON occurrence in people infected with COVID-19)

  • Optimizes the immune response from T-killer cells and lymphocytes

  • Lowers chronic inflammation

  • Has potential antiviral effects (one study showed a major reduction in influenza symptoms with Thymosin Beta-4 administration)

  • Neurological effects are noteworthy; successfully used in patients with traumatic brain injury (TBI) and stroke

  • Helps to regenerate damaged cells

  • Reduces joint inflammation

  • Helps to heal wounds faster than usual while reducing pain and tissue scarring

  • Speeds up hair growth

  • Improves endurance by affecting stamina levels

  • Promotes migration of other cells, including stem cells and tumor cells via G-actin-sequestering

  • Suppresses production of inflammatory IL-8, TNFa

  • Up-regulates hepatocyte growth factor, down-regulates platelet-derived growth factor

  • Antimicrobial, anti-inflammatory, anti-apoptotic

  • Helps prevent hyper coagulability seen with chronic illness.

  • Increases oxidative enzymes to protect cells and tissues from oxidative damage

Dosage: 10-30 doses per vial.  Dose daily for up to 3 months or until your condition resolves. Does not have to be used locally at the site of injury.  Higher doses can be used for a short time.

Side Effects: Less than placebo if dosage is administered correctly.  Some people note getting ahead rush immediately following injection, but this only lasts for a few minutes.

Warning:  TB500 is banned by WADA for elite athletes who fall under that banner.

Description: TB500 is the four amino acid fragment (1-4) of the 43 amino acid full-length Thymosin Beta 4 (TB4), produced by the thymus gland.  TB4 has multiple active sections that code for different and overlapping functions.  TB500 is the workhorse, possessing the immune modulatory, angiogenic, healing, anti-inflammatory, cellular protective and repair actions of full-length TB4.  TB500 is actually better than the full-length TB4! It is a more potent anti-fibrotic, and it has 10 times the potency of full length TB4 by weight. It does not stimulate mast cell activation (segment 16-38). Its reduced molecular weight allows TB500 to cross the blood-brain barrier and penetrate biofilms.

TB500’s effects are accomplished through its influence on blood cell and blood vessel development, cellular differentiation, and cell migration. A major part of its healing capability stems from the peptide’s regulation of actin, a cell building protein essential to healing and wound repair. TB500 further enhances stem cell differentiation, cell mobility, and increases cell survival. Speeds up the process through which actin builds cells in the body. Actin is a protein responsible for the action and formation of most of the cells in our bodies. This promotes positive cell growth in injured areas, thus speeding up the healing process. TB500 is an essential component of cell structure, which plays a crucial role in protecting, regenerating, and remodeling of injured or damaged tissues.

Want to learn more?

Research Study:  Thymosin Beta 4 as a restorative/regenerative therapy for neurological injury and neurodegenerative diseases

Research Study:  Thymosin β4 promotes the recovery of peripheral neuropathy in type II diabetic mice


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