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Peptide Spotlight: MOTS-c

Boost Mitochondria, Insulin Sensitivity, and Fat Loss

Primary Benefit:  MOTS-c upregulates mitochondrial function at the cellular level, providing more energy, potential fat loss, and improved insulin sensitivity. 


  • Enhances the mitochondria's ability to react to metabolic stress. 

  • Very useful for anti-aging, as metabolic health and mitochondria play an important role in longevity.

  • VERY potent for adiposity reduction (i.e. burning fat).

  • Enhances cold tolerance.

  • Upregulates brown adipose tissue (BAT) thermogenic gene expression, increases white fat “browning”.

  • Counteracts diet-induced and age-dependent insulin resistance.

  • Fights the weight gain caused by a high-fat Western diet and normalizes the metabolism.

  • Promotes mitochondrial biogenesis.

  • Activates AMP-kinase which improves glucose metabolism.

  • Improves insulin sensitivity and glucose metabolism by increasing glucose uptake into muscle cells.

  • Considered an exercise-mimetic, meaning it imitates exercise on the body

  • Promotes weight loss and heart health.

  • Promotes bone formation.

  • Has similar benefits of the drug Methotrexate without any side effects.

  • Helps those who physically cannot exercise to still get some similar benefits.

  • Stimulates bone formation and combats osteoporosis.

Dosage: 5 mg 2-3x a week for 4-6 weeks. 

Repeat 1-2x a year.

Optimal timing is in the morning before endurance exercise.  

Optional Dosage: Can dose up to 10 mg all at once if desired.

Side Effects:  No noted side effects.  

Description:  Mitochondrial-Derived Peptide(MOTS-c) promotes metabolic homeostasis while reducing obesity and insulin resistance. Its primary target organ appears to be the skeletal muscle.  MOTS-c’s cellular actions inhibit the folate cycle, leading to AMP-activated protein kinase (AMPK) activation. AMPK is acellular enzyme that when activated enhances fat burning (i.e. lipolysis) and promotes longevity. Some people respond well to it, others who are much leaner with strong, up-regulated mitochondrial activity already, don't (biochemical individuality is always the ultimate determinant).  It’s also been referred to as “exercise in a bottle” because it can mimic some of the effects of exercise by activating the AMPK pathway.

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