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DNA Mutations and Methylation Issues

Our ability to detox synthetic folic acid, the most abundant nutrient in our diet, is a complicated topic.   Start with reading this blog post to get an overview.

Folic Acid can cause issues with sleep, ADHD, high cholesterol, anxiety, depression, high blood pressure, and digestion.   Check your protein powders, energy drinks, crackers, cookies, bread, pasta, rice and any other foods with wheat or grains.   If it says ENRICHED or FORTIFIED, then find another brand that is NOT enriched or fortified.   Synthetic Folic Acid is not tolerated by our brains and makes us "tired but wired".    Avoiding Folic Acid for just a couple of days may make a huge improvement in your sleep, and over the long term may help with many chronic health issues.


TMG stands for TriMethylGylcine.   TMG helps convert homocysteine to methionine.  DNA Mutations such as MTHFR and low levels of B Vitamins may cause a buildup of homocysteine. 


Homocysteine is a common amino acid, and high levels are associated with heart disease and other inflammatory illnesses. High homocysteine levels are also linked to blood vessel issues, such as blockage, and may impact the brain, lungs or heart. There are also associations to cancer, liver disease, peripheral neuropathy and mental illness. Interestingly, high homocysteine levels also present with low levels of B vitamins, such as folate and B12. TMG works along with these vitamins to help support proper methylation and reduce homocysteine levels.


SAMe might help you if you have the COMT or AHCT DNA Mutations.  Please listen to this short podcast before trying SAMe!


90% of SAMe is used to make creatine and phosphatidylcholine. You might try supplementing with those directly instead, it saves the process of making more SAMe.  A byproduct of SAMe is homocysteine.  SAMe also speeds up the CBS enzyme which produces an excess of hydrogen sulfide gasses. 


If you choose to supplement, choose a brand with an acid resistant capsule that comes in blister pack or uses desiccant.  Otherwise it won't do much.


Try this test to see if SAMe will help you:  Take 50 - 100 mg SAM in the evening. If you fall asleep and/or calm down, then your Methylation pathways are open.  If you become irritable or get a headaches then SAMe is not right for you, your methylation pathways are not working.  Neutralize symptoms with niacin (nicotinic acid).


DIM stands for Diindolymethane.  DIM supplementation helps to metabolize estrogen into more good metabolites than the potentially harmful metabolites. It also appears to help destroy cancer cells and reduce inflammation.  Certain DNA mutations such as MTHFR, COMT, etc can affect your ability to break down estrogen and clear it from the body.  This can happen in men and women.   Signs of estrogen dominance include recurring PMS, weight gain, fibrocystic breasts, endometriosis, anxiety, depression, bloating, brain fog, insomnia, breast tenderness, mood swings, abdominal weight, lethargy/fatigue, irritability, and/or low libido.

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